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MONDAY, Sept. 10, 2018 (HealthDay News) — Higher levels of aldosterone are associated with insulin resistance and incident type 2 diabetes mellitus among multiethnic individuals, according to a study published in the Sept. 4 issue of the Journal of the American Heart Association<\/i>.<\/p>\n
Joshua J. Joseph, M.D., from The Ohio State University in Columbus, and colleagues assessed associations between aldosterone and plasma renin activity with fasting plasma glucose, insulin resistance, \u03b2-cell function, and incident diabetes mellitus among 1,570 adults participating in the Multiethnic Study of Atherosclerosis.<\/p>\n
The researchers found that there were 116 cases of incident diabetes mellitus over 10.5 years of follow-up. A 100 percent increase in log-aldosterone was associated with a 2.6 mg\/dL higher fasting plasma glucose, 15 percent higher homeostatic model assessment of insulin resistance (HOMA2-IR) and 6 percent higher HOMA2-\u03b2 (P < 0.01). Further, a one-standard-deviation increase in log-aldosterone was associated with a 44 percent higher risk of incident diabetes mellitus (P < 0.01). The greatest increase in risk (142 percent; P < 0.01) was seen in Chinese-Americans (P for interaction, 0.09 versus other ethnicities). In fully adjusted models, log-plasma renin activity was not associated with incident diabetes mellitus.<\/p>\n
“Aldosterone is associated with glucose homeostasis and diabetes mellitus risk with graded associations among Chinese-Americans and blacks, suggesting that pleiotropic effects of aldosterone may represent a modifiable mechanism in diabetes mellitus pathogenesis with potential racial\/ethnic variation,” the authors write.<\/p>\n