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WEDNESDAY, Feb. 21, 2018 (HealthDay News) — For patients who have undergone total hip or knee arthroplasty, extended prophylaxis with aspirin does not differ significantly from rivaroxaban for venous thromboembolism prevention, according to a study published in the Feb. 21 issue of the New England Journal of Medicine<\/i>.<\/p>\n
David R. Anderson, M.D., from Dalhousie University in Halifax, Canada, and colleagues conducted a multicenter randomized trial involving patients who were undergoing total hip (1,804 patients) or knee (1,620 patients) arthroplasty. All patients received oral rivaroxaban until postoperative day 5 and were then randomized to continue rivaroxaban or switch to aspirin for nine or 30 days after total knee or total hip arthroplasty, respectively. Patients were followed for 90 days.<\/p>\n
The researchers found that venous thromboembolism occurred in 0.64 and 0.7 percent of patients in the aspirin and rivaroxaban groups, respectively (difference, 0.06 percentage points; 95 percent confidence interval [CI], \u22120.55 to 0.66; P < 0.001 for noninferiority and P = 0.84 for superiority). Major bleeding complications occurred in 0.47 and 0.29 percent of patients in the aspirin and rivaroxaban groups, respectively (difference, 0.18 percentage points; 95 percent CI, \u22120.65 to 0.29; P = 0.42). Clinically important bleeding occurred in 1.29 and 0.99 percent of patients in the aspirin and rivaroxaban groups, respectively (difference, 0.3 percentage points; 95 percent CI, \u22121.07 to 0.47; P = 0.43).<\/p>\n
“Extended prophylaxis with aspirin was not significantly different from rivaroxaban in the prevention of symptomatic venous thromboembolism,” the authors write.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
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