Obese participants also had higher concentrations of high-sensitivity C-reactive protein, interleukin-6<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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THURSDAY, July 6, 2023 (HealthDay News) — Obesity is associated with increased inflammation and prolonged symptoms after mild traumatic brain injury (mTBI), according to a study published online June 27 in the Journal of Neurology, Neurosurgery & Psychiatry<\/em>.<\/p>\n Shawn R. Eagle, Ph.D., from the University of Pittsburgh, and colleagues examined the role of obesity in recovery of symptoms, functional outcome, and inflammatory blood biomarkers after mTBI in a prospective study of patients with acute mTBI who were enrolled \u00e2\u0089\u00a424 hours after injury and followed for 12 months. Seven hundred seventy hospitalized patients who were obese (body mass index [BMI] > 30.0 kg\/m\u00c2\u00b2) or had a healthy BMI (18.5 to 24.9 kg\/m\u00c2\u00b2) were enrolled.<\/p>\n The researchers found that compared with participants with healthy body mass, obese participants had higher concentrations of high-sensitivity C-reactive protein one day after injury, at two weeks, and at six months (mean differences, 0.65, 0.99, and 1.08, respectively). In addition, obese participants had higher concentrations of interleukin-6 at two weeks and six months (mean differences, 0.37 and 0.42, respectively). A higher Rivermead Post-Concussion Symptoms Questionnaire total score was seen at six and 12 months for obese participants (mean differences, 2.79 and 2.37, respectively).<\/p>\n “Our hope is to build our research program to find treatments that reduce inflammation and improve overall health for obese patients after sustaining an mTBI,” Eagle said in a statement. “Our findings suggest clinicians should consider higher body mass as a risk factor for poor responses to mTBI.”<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n