Larger absolute risk reduction seen among those with the highest genetic risk<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
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THURSDAY, June 22, 2023 (HealthDay News) — Physical activity is important for type 2 diabetes prevention, particularly for those with a high genetic risk, according to a study published online June 5 in the British Journal of Sports Medicine<\/em>.<\/p>\n Mengyun Luo, from the University of Sydney, and colleagues used accelerometry data from 59,325 participants in the U.K. Biobank to examine the prospective dose-response relationships between total and intensity-specific physical activity and incident type 2 diabetes when accounting for and stratified by different levels of genetic risk.<\/p>\n The researchers found that during a median follow-up of 6.8 years, there was a strong linear, dose-response association between moderate- to vigorous-intensity physical activity (MVPA) and incident type 2 diabetes, even after adjusting for genetic risk. Risk declined for higher levels of MVPA (hazard ratios: 0.63 for 5.3 to 25.9 minutes\/day; 0.41 for 26.0 to 68.4 minutes\/day; 0.26 for >68.4 minutes\/day), compared with the least active participants. There was a significant additive interaction observed between MVPA and genetic risk score, suggesting those with higher genetic risk have larger absolute risk differences by MVPA levels.<\/p>\n “These findings can inform future guidelines development and interventions to prevent type 2 diabetes,” the authors write. “Physical activity, specifically MVPA, is beneficial, especially in those with high genetic risk, and should be promoted as a priority strategy for type 2 diabetes prevention.”<\/p>\n