No improvement seen in favorable functional outcome at six months, but reduced risk of death at 28 days after injury<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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THURSDAY, June 15, 2023 (HealthDay News) — For adults with major trauma at risk for trauma-induced coagulopathy, tranexamic acid administered before hospital admission is not associated with improvement in favorable functional outcome at six months, according to a study published online June 14 in the New England Journal of Medicine<\/em> to coincide with the annual Critical Care Reviews Meeting, held from June 14 to 16 in Belfast, Ireland.<\/p>\n Russell L. Gruen, M.B., B.S., Ph.D., from the Australian National University in Canberra, and colleagues randomly assigned adults with major trauma who were at risk for trauma-induced coagulopathy to receive tranexamic acid administered before hospital admission and after arrival at the hospital or matched placebo (661 and 646 patients, respectively).<\/p>\n The researchers found that survival with a favorable functional outcome at six months occurred in 53.7 and 53.5 percent of patients in the tranexamic acid and placebo groups, respectively (risk ratio, 1.00; 95 percent confidence interval, 0.90 to 1.12; P = 0.95). At 28 days after injury, 17.3 and 21.8 percent of patients in the tranexamic acid and placebo groups, respectively, had died (risk ratio, 0.79; 95 percent confidence interval, 0.63 to 0.99), and by six months, 19.0 and 22.9 percent had died (risk ratio, 0.83; 95 percent confidence interval, 0.67 to 1.03). There was no meaningful difference observed between the groups in the number of serious adverse events, including vascular occlusive events.<\/p>\n “The results appear to confirm the early survival benefit of tranexamic acid, but no benefit with respect to a favorable functional outcome at six months,” write the authors of an accompanying editorial.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n