For female patients aged at least 66 years, odds of prevalent CVD up with locally advanced and metastatic disease
By Elana Gotkine HealthDay Reporter
MONDAY, Jan. 6, 2025 (HealthDay News) — Individuals with advanced breast cancer at diagnosis are more likely to have prevalent cardiovascular disease (CVD), according to a study published online Jan. 2 in JAMA Network Open.
In a population-based case-control study, Ivan Angelov, from the University of Texas MD Anderson Cancer Center in Houston, and colleagues examined whether female patients aged at least 66 years presenting with advanced breast cancers are more likely to have prevalent CVD compared with those with early-stage breast cancer at the time of diagnosis.
The full analytic cohort included 19,292 matched female patients; 9,478 had prevalent CVD. The researchers found that the odds of prevalent CVD were significantly increased in individuals with locally advanced or metastatic cancer at diagnosis in propensity score-matched, multivariable-adjusted models (odds ratio, 1.10; 95 percent confidence interval, 1.03 to 1.17; P = 0.007). This association was seen for hormone receptor-positive breast cancer (odds ratio, 1.11; 95 percent confidence interval, 1.03 to 1.19; P = 0.006), but not hormone receptor-negative (odds ratio, 1.02; 95 percent confidence interval, 0.86 to 1.21; P = 0.83). When examining locally advanced and metastatic disease separately, odds ratios were directionally consistent (odds ratios [95 percent confidence intervals], 1.09 [1.02 to 1.17; P = 0.02] and 1.20 [0.94 to 1.54; P = 0.15], respectively) among all receptor subtypes.
“This retrospective case-control study found an association between prevalent CVD and more advanced stage of breast cancer at diagnosis, independent of factors associated with delayed diagnosis and shared risk,” the authors write.
One author disclosed ties to Artidis Research, Varian Medical Systems, and Oncora Medical.
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