Cardiometabolic pattern of multimorbidity shows the highest risk for kidney function decline
By Lori Solomon HealthDay Reporter
THURSDAY, Dec. 26, 2024 (HealthDay News) — Multimorbidity is strongly associated with accelerated kidney function decline in older age, according to a study published online Dec. 17 in the Journal of the American Geriatrics Society.
Giorgi Beridze, M.D., from the Karolinska Institutet and Stockholm University, and colleagues examined the role of multimorbidity (two or more conditions) and the development of kidney function decline. The analysis included data from 3,094 individuals participating in the Swedish National study on Aging and Care in Kungsholmen, who were followed for 15 years.
The researchers found an independent dose-response relationship between the number of chronic conditions and absolute (β = −0.05) and relative (hazard ratio, 1.23) declines in estimated glomerular filtration rate. Five patterns of multimorbidity existed in the cohort. The unspecific, low-burden pattern had the lowest morbidity burden and served as the reference category. The unspecific, high-burden and cardiometabolic patterns showed accelerated absolute (β = −0.15 and −0.77, respectively) and relative declines (hazard ratios, 1.45 and 3.45, respectively). The cognitive and sensory pattern showed accelerated relative decline (hazard ratio, 1.53). There were no associations seen for the psychiatric and respiratory pattern.
“Targeted interventions aimed at individuals with cardiometabolic multimorbidity could help mitigate the risk of kidney function decline in older age,” the authors write.
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