Adjusted odds ratio for asthma was 22.3 for patients with bronchiectasis and situs inversus totalis, indicative of PCD
By Elana Gotkine HealthDay Reporter
FRIDAY, Dec. 20, 2024 (HealthDay News) — Most children with likely primary ciliary dyskinesia (PCD) have asthma, according to a research letter published online Dec. 9 in JAMA Network Open.
Joe Zein, M.D., Ph.D., from the Mayo Clinic in Scottsdale, Arizona, and colleagues conducted a case-control study to examine the association between PCD and asthma in children aged 18 years or younger. The combination of two diagnoses that are unlikely to occur together in the absence of PCD, specifically bronchiectasis and situs inversus totalis (B-SIT), was analyzed; individuals with B-SIT were then asked whether they also had a diagnosis of asthma. This study included 124 B-SIT patients and 142 controls matched for age, sex, ethnicity, and race: nine children with B-SIT and 27 controls from the Indiana Network for Patient Care Research (INPCR) cohort and 115 cases and 115 controls from the validation cohort, TriNetX.
The researchers found that in the INPCR cohort, all nine B-SIT children and one control had asthma. In the TriNetX cohort, 84 with B-SIT and 12 controls had asthma. The adjusted odds ratio was 22.3 for patients with B-SIT having asthma.
“In summary, children with PCD may need to be evaluated for asthma,” the authors write. “Consideration should also be given to whether some children with asthma may have cardinal features of PCD.”
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