Systemic inflammation is important mediator between diabetes-related markers and overactive bladder
By Lori Solomon HealthDay Reporter
TUESDAY, June 4, 2024 (HealthDay News) — Markers of diabetes are positively associated with overactive bladder (OAB), according to a study published online April 28 in Frontiers in Endocrinology.
Qingliu He, from Jinjiang Municipal Hospital in Quanzhou, China, and colleagues used data from six cycles of the U.S. National Health and Nutrition Examination Survey (23,863 participants) to examine the relationship between diabetes and OAB.
The researchers found that diabetes mellitus participants’ OAB prevalence was 77 percent higher versus those without diabetes. With increasing quartiles of diabetes-related markers, the odds of OAB monotonically increased in three models. There was a linear association between glycohemoglobin and OAB. The associations between diabetes-related markers (glycohemoglobin, fasting glucose, and insulin) with OAB were significantly mediated by white blood cells (7.23, 8.08, and 17.74 percent, respectively) and partly mediated by neutrophils (6.58, 9.64, and 17.93 percent, respectively). Machine learning of the XGBoost model predicted glycohemoglobin is the most important indicator of OAB.
“Our hypothesis based on the analysis results of the association between OAB, diabetes, and systemic inflammation is that diabetes mellitus may increase OAB risk by promoting systemic inflammation,” the authors write.
Copyright © 2024 HealthDay. All rights reserved.
