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Many Untreated CIN2 Lesions Regress Spontaneously

Regression of cervical intraepithelial neoplasia grade 2 lesions especially likely in younger women

WEDNESDAY, Feb. 28, 2018 (HealthDay News) — Most untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions regress, especially among women younger than 30 years, according to a review published online Feb. 27 in The BMJ.

Karoliina Tainio, M.D., from the University of Helsinki in Finland, and colleagues conducted a systematic review and meta-analysis to estimate the regression, persistence, and progression of untreated CIN2 lesions managed conservatively. Data were included from 36 studies with 3,160 women.

The researchers found that the pooled rates were 50 percent for regression, 32 percent for persistence, and 18 percent for progression at 24 months. The rates were 60, 23, and 11 percent, respectively, in a subgroup analysis of 1,069 women aged younger than 30 years. In prospective studies, the rate of non-compliance was about 10 percent.

“Most CIN2 lesions, particularly in young women (<30 years) regress spontaneously," the authors write. "Active surveillance, rather than immediate intervention, is therefore justified, especially among young women who are likely to adhere to monitoring."

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