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Balanced Crystalloids Cut Kidney Events in Critically Ill

For noncritically ill patients, no difference in number of hospital-free days for crystalloids versus saline

WEDNESDAY, Feb. 28, 2018 (HealthDay News) — Balanced crystalloids offer some benefits versus saline in critically ill and noncritically ill adults, according to two studies published online Feb. 27 in the New England Journal of Medicine to coincide with the Society of Critical Care Medicine’s Annual Critical Care Congress, held from Feb. 25 to 28 in San Antonio.

Matthew W. Semler, M.D., from the Vanderbilt University Medical Center in Nashville, Tenn., and colleague assigned 15,802 adults in five intensive care units (ICUs) to receive saline (7,860 patients) or balanced crystalloids (7,942 patients). The researchers found that 14.3 percent of patients in the balanced crystalloid group and 15.4 percent in the saline group had a major adverse kidney event (marginal odds ratio, 0.90; 95 percent confidence interval, 0.82 to 0.99; P = 0.04).

Wesley H. Self, M.D., M.P.H., from also from the Vanderbilt University Medical Center, and colleagues compared balanced crystalloids with saline among 13,347 adults treated with intravenous crystalloids in the emergency department who were hospitalized outside an ICU. There was no difference noted between the groups in the number of hospital-free days (median, 25 in each group; adjusted odds ratio with balanced crystalloids, 0.98; 95 percent confidence interval, 0.92 to 1.04; P = 0.41). Compared with saline, balanced crystalloids resulted in a lower incidence of major adverse kidney events within 30 days (4.7 versus 5.6 percent; adjusted odds ratio, 0.82; 95 percent confidence interval, 0.70 to 0.95; P = 0.01).

“Treatment with balanced crystalloids did not result in a shorter time to hospital discharge (hospital-free days) than treatment with saline,” Self and colleagues write.

Several authors in the Self study disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text – Semler

Abstract/Full Text – Self


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