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Coronary Artery Dz Extent Similar in Men, Women With T1DM

Extent of CAD similar for those admitted for coronary angiography; no difference in long-term mortality

MONDAY, Feb. 26, 2018 (HealthDay News) — For patients with type 1 diabetes, the extent of coronary artery disease (CAD) is similar in women and men admitted for coronary angiography, according to a study published online Feb. 20 in Diabetes Care.

Viveca Ritsinger, from the Karolinska Institute in Sweden, and colleagues followed patients with type 1 diabetes undergoing coronary angiography from 2001 to 2013 for mortality until Dec. 31, 2013. A total of 2,776 patients (mean age, 58 years) were followed for 7.2 years.

The researchers found that there was no substantial difference in indications for coronary angiography for women and men. Women had somewhat less severe extent of CAD (normal angiogram, 23.5 percent versus 19.1 percent; three-vessel and left main stem disease, 34.5 versus 40.4 percent; P = 0.002); no difference was seen in mortality (adjusted hazard ratio, 1.03; 95 percent confidence interval, 0.88 to 1.2; P = 0.754). For the first year, the standard mortality ratio was 7.49 (95 percent confidence interval, 5.73 to 9.62) and 4.58 (95 percent confidence interval, 3.6 to 5.74) for women and men, respectively.

“In patients with type 1 diabetes admitted for coronary angiography, the extent of CAD was almost similar in women and men, and total long-term mortality did not differ,” the authors write. “These data support that type 1 diabetes attenuates the cardiovascular risk difference seen in men and women in the general population.”

Several authors disclosed financial ties to the pharmaceutical industry.

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