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Maternal Vaccination Not Tied to Infant Hospitalization, Death

Vaccination with influenza and Tdap not linked to risk of infant hospitalization, death in first six months

TUESDAY, Feb. 20, 2018 (HealthDay News) — Maternal receipt of influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines is not associated with infant hospitalization or death in the first six months of life, according to a study published online Feb. 20 in Pediatrics.

Lakshmi Sukumaran, M.D., M.P.H., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues examined the correlation between maternal receipt of influenza and Tdap vaccines and the risk of infant hospitalization or death. Singleton, live-birth pregnancies in the Vaccine Safety Datalink between 2004 and 2014 were included.

The researchers identified 413,034 live births in the population. In the first six months of life, 25,222 infants had hospitalizations and 157 infants died. There was no correlation between infant hospitalization and maternal influenza (adjusted odds ratio, 1; 95 percent confidence interval, 0.96 to 1.04) or Tdap (adjusted odds ratio, 0.94; 95 percent confidence interval, 0.88 to 1.01) vaccinations. No correlation was identified between infant mortality and maternal influenza (adjusted odds ratio, 0.96; 95 percent confidence interval, 0.54 to 1.69) or Tdap (adjusted odds ratio, 0.44; 95 percent confidence interval, 0.17 to 1.13) vaccinations.

“These findings support the safety of current recommendations for influenza and Tdap vaccination during pregnancy,” the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

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