Stronger diet effect seen in Gleason grade group >6 and in International Society of Urological Pathology grade 3 + 4 + 5 tumors
By Elana Gotkine HealthDay Reporter
WEDNESDAY, April 19, 2023 (HealthDay News) — Adherence to a Western diet may have a detrimental effect on the risk for prostate cancer, according to a study published online April 19 in BJU International.
Adela Castell ³, Ph.D., from the University of Alcal ¡ in Madrid, and colleagues examined the association between three dietary patterns (Western, Prudent, and Mediterranean) and prostate cancer risk in a study involving 15,296 men recruited during 1992 to 1996. The associations between dietary patterns and prostate cancer risk (global, for Gleason grade groups 6 and >6, and for International Society of Urological Pathology [ISUP] grade 1 + 2 and ISUP grade 3 + 4 + 5) were examined.
The researchers found that for the Prudent and Mediterranean dietary patterns, there was no effect on prostate cancer risk, while there was a suggestion of a detrimental effect of the Western dietary pattern (hazard ratioquartile[Q]4vsQ1, 1.29; 95 percent confidence interval, 0.96 to 1.72). This effect was only seen for Gleason grade group >6 (hazard ratioQ3vsQ1, 1.61; 95 percent confidence interval, 1.00 to 2.59; hazard ratioQ4vsQ1, 1.60; 95 percent confidence interval, 0.96 to 2.67) and was stronger for ISUP grade 3 + 4 + 5 tumors (hazard ratioQ2vsQ1, 1.97; 95 percent confidence interval, 0.98 to 3.93; hazard ratioQ3vsQ1, 2.72; 95 percent confidence interval, 1.35 to 5.51; hazard ratioQ4vsQ1, 2.29; 95 percent confidence interval, 1.07 to 4.92).
“Our results indicate that avoiding unhealthy dietary habits could be the best nutritional strategy to prevent aggressive prostate cancer,” Castell ³ said in a statement.
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